FB2026_03 , released September 17, 2026
Gene Group: SPHINGOMYELINASES
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General Information
Name
SPHINGOMYELINASES
Species
D. melanogaster
Symbol
SMASE
FlyBase ID
FBgg0001378
Date last reviewed
2023-02-02
Number of members
5
Description
Description
Sphingomyelinases catalyze the hydrolysis of sphingomylein (in mammals) or ceramide phosphoethanolamine (the analog of sphingomylein in Drosophila) into ceramide and choline phosphate. Distinct acid or neutral sphingomyelinases (aSMase and nSMase, respectively) exist whose activity depends on the pH of the microenvironment - e.g. aSMases operate within the lysosomal compartment. (Adapted from FBrf0161471 and FBrf0255710.)
Notes on Group

CG32052 is listed as an acidic sphingomyelinase in FBrf0161471 and FBrf0255710 but is excluded from this group because it lacks a 'Sphingomyelin phosphodiesterase' (IPR011160) protein signature and its human ortholog (SMPDL3A) has been demonstrated to lack sphingomyelin phosphodiesterase activity (PMID:25288789, PMID:26783088).

Source Material
The SPHINGOMYELINASES Gene Group has been compiled using the following publication(s): Chen et al., 2022 and Renault et al., 2002 .
Key Gene Ontology (GO) terms
Molecular Function
sphingomyelin phosphodiesterase activity
Biological Process
Cellular Component
Enzymatic activity
Enzyme name (EC)
sphingomyelin phosphodiesterase (3.1.4.12)
Related Gene Groups
Parent group(s)
PHOSPHORIC DIESTER HYDROLASES
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
SPHINGOMYELIN PHOSPHODIESTERASES
SMPDE
SMASE
SPHINGOMYELINASES
Secondary FlyBase ID(s)
References (4)