Drosophila angiotensin-converting enzyme-like peptidyl-dipeptidases are secreted peptidases that remove the two terminal amino acids from peptides by hydrolysis. They share ancestry with the membrane-anchored mammalian angiotensin I-converting enzyme (ACE). Although the endogenous target(s) of these enzymes have not been identified, they have been shown to cleave various mammalian ACE peptide hormone targets and peptide hormones from other insects. They belong to MEROPS family M2. (Adapted from FBrf0129770, FBrf0100789 and FBrf0105845.)