Gene Group: NUCLEASES (HYDROLYTIC MECHANISM)

General Information

Name

NUCLEASES (HYDROLYTIC MECHANISM)

Species

D. melanogaster

Symbol

NASE

FlyBase ID

FBgg0001544

Date last reviewed

2020-06-16

Number of members

104

Description

Nucleases are considered as molecular scissors, which catalyze the cleavage of phosphodiester bonds between the sugars and the phosphate moieties of nucleic acids. They play important role in DNA proofreading during replication, base, DNA repair, homologous recombination, and DNA/RNA turnover. The majority of nucleases are classified as hydrolases (this grouping) though a few endonucleases are classed as lyases. (Adapted from PMID:20854710 and PMID:12483517).

Notes on Group

Source Material

The NUCLEASES (HYDROLYTIC MECHANISM) Gene Group has been compiled using the following publication(s): Liu et al., 2022, Bellendir et al., 2017, Azlan et al., 2016, Barclay et al., 2014, Temme et al., 2014, Lim et al., 2008, Kanno et al., 2007, Kupsco et al., 2006, Luo and Kaguni, 2005, Ishikawa et al., 2004, Lee et al., 2004, Oshige et al., 2004, Bernstein et al., 2001, Filippov et al., 1997, Aoyagi et al., 1994, Nugent et al., 1993, and Reyland et al., 1988 .

Key Gene Ontology (GO) terms

Molecular Function

nuclease activity

Biological Process

Cellular Component

Related Gene Groups

Parent group(s)

ESTER BOND HYDROLASES

Component group(s)

DNA NUCLEASES

RNA NUCLEASES

UNCLASSIFIED NUCLEASES