FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Complex: RNA POLYMERASE I
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General Information
Name
RNA POLYMERASE I
Species
D. melanogaster
Symbol
RNAPI
FlyBase ID
FBgg0001647
Date last reviewed
2023-08-08
Number of members
13
Description
Description
RNA polymerase I (RNAP I) synthesizes the ribosomal RNA precursor that is processed into most ribosomal RNAs (rRNAs). It comprises 12-14 subunits (12 in D. melanogaster), ten of which form a structurally conserved catalytic core with additional subunits located on the periphery. Notably, five RNAP I subunits are shared with the other two nuclear RNAPs, and two others are shared between RNAPs I and III. (Adapted from FBrf0247389.)
Notes on Group

D. melanogaster lacks an identifiable ortholog of RNAP I subunits RPA14 (yeast) and RPA34 (yeast)/POLR1G (human) (FBrf0244832, FBrf0247389).

Source Material
The RNA POLYMERASE I Gene Group has been compiled using the following publication(s): Palumbo and Knutson, 2024 and Marygold et al., 2020 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-directed RNA polymerase activity
Biological Process
transcription by RNA polymerase I
Cellular Component
RNA polymerase I complex
Enzymatic activity
Enzyme name (EC)
DNA-directed RNA polymerase (2.7.7.6)
Related Gene Groups
Parent group(s)
RNA POLYMERASES
Other related group(s)
RNA POLYMERASE CATALYTIC SUBUNITS
Members (13)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RNAPI
RNA POLYMERASE I
Secondary FlyBase ID(s)
References (3)