FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: L-MALATE DEHYDROGENASES
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General Information
Name
L-MALATE DEHYDROGENASES
Species
D. melanogaster
Symbol
LMDH
FlyBase ID
FBgg0001710
Date last reviewed
2023-09-12
Number of members
4
Description
Description
L-malate dehydrogenases are NAD-dependent oxidoreductases that catalyze interconversion of the substrates malate and oxaloacetate. This reaction plays key role in the malate/aspartate shuttle across the mitochondrial membrane, and in the tricarboxylic acid cycle within the mitochondrial matrix. (Adapted from PMID:12537350.)
Notes on Group

Mdh1 encodes a cytosolic enzyme, whereas Mdh2, CG10748 and CG10749 are paralogs that encode mitochondrial enzymes - Mdh2 is expressed ubiquitously, whereas CG10748 and CG10749 are testis-specific.

Source Material
The L-MALATE DEHYDROGENASES Gene Group has been compiled using the following publication(s): Zaru and Marygold, 2025, François et al., 2023, and Voelker et al., 1979 .
Key Gene Ontology (GO) terms
Molecular Function
L-malate dehydrogenase (NAD+) activity
Biological Process
Cellular Component
Enzymatic activity
Enzyme name (EC)
(S)-malate dehydrogenase (NAD(+), oxaloacetate-forming) (1.1.1.37)
Related Gene Groups
Parent group(s)
MALATE DEHYDROGENASES
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
LMDH
L-MALATE DEHYDROGENASES
Secondary FlyBase ID(s)
References (5)