FB2026_02 , released June 18, 2026
Gene Group: NEUTRAL TRIGLYCERIDE LIPASES
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General Information
Name
NEUTRAL TRIGLYCERIDE LIPASES
Species
D. melanogaster
Symbol
NTRLIP
FlyBase ID
FBgg0001739
Date last reviewed
2021-07-14
Number of members
28
Description
Description
Lipases, generally defined as triacylglycerol hydrolases (EC 3.1.1.3), cleave the carboxylester linkages in triacylglycerol (TAG) to produce diacylglycerol (DAG) and a carboxylate. In insects, TAGs are used for energy storage and for storage of fatty acid precursors for semiochemicals, while DAGs are the main form of transported lipid. Lipases thus control key steps in lipid uptake, transport and utilisation. The neutral lipases are so named for their ability to hydrolyse neutral lipids such as TAGs, DAGs and monoacylglycerols (MAGs), though members of this family are also known to hydrolyse the sn-1 position in phospholipids and galactolipids. Neutral lipases are defined by Pfam domain PF00151 (corresponding to InterPro IPR013818). (Adapted from FBrf0208359.)
Notes on Group

Yp1, Yp2, Yp3, CG14034 and CG10116 lack the consensus Ser-His-Asp catalytic triad and are therefore predicted to be catalytically inactive (FBrf0208359). They are excluded from this group.

With the exception of CG18641, CG6847, CG34447 and CG34448, all D. melanogaster neutral lipases lack the consensus motifs (a β9 loop and a lid which cover the active site) required for TAG hydrolytic activity in mammalian enzymes. Therefore, they may not be functional triglyceride lipases. (FBrf0208359)

Source Material
The NEUTRAL TRIGLYCERIDE LIPASES Gene Group has been compiled using the following publication(s): Horne et al., 2009 .
Key Gene Ontology (GO) terms
Molecular Function
triacylglycerol lipase activity
Biological Process
Cellular Component
Enzymatic activity
Enzyme name (EC)
triacylglycerol lipase (3.1.1.3)
Related Gene Groups
Parent group(s)
TRIGLYCERIDE LIPASES
Members (28)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
NTRLIP
NEUTRAL TRIGLYCERIDE LIPASES
Secondary FlyBase ID(s)
References (3)