FB2026_03 , released September 17, 2026
Gene Group: ACID TRIGLYCERIDE LIPASES
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General Information
Name
ACID TRIGLYCERIDE LIPASES
Species
D. melanogaster
Symbol
ATRLIP
FlyBase ID
FBgg0001740
Date last reviewed
2021-07-14
Number of members
23
Description
Description
Lipases, generally defined as triacylgycerol hydrolases (EC 3.1.1.3), cleave the carboxylester linkages in triacylglycerol (TAG) to produce diacylglycerol (DAG) and a carboxylate. In insects, TAGs are used for energy storage and for storage of fatty acid precursors for semiochemicals, while DAGs are the main form of transported lipid. Lipases thus control key steps in lipid uptake, transport and utilisation. The acid lipases or abhydrolipase family are so named because the founding member, the gastric lipase of mammals, was found to function at acidic pH. The acid lipases predominantly hydrolyse TAGs and cholesterol esters, and are defined by Pfam domain PF04083 (corresponding to InterPro IPR006693). (Adapted from FBrf0208359.)
Notes on Group

Bacterially expressed Lip3 has weak TAG lipase activity on short-chain fatty acid glyceryl trioctanoate but no detectable activity on glyceryl trioleate, a more physiological substrate (FBrf0243470). Lip3 expressed in mammalian cell culture does not have TAG, DAG or MAG activity - instead, lipidomics analysis of a Lip3 mutant suggests Lip3 is a putative phospholipase (FBrf0254005).

Source Material
The ACID TRIGLYCERIDE LIPASES Gene Group has been compiled using the following publication(s): Horne et al., 2009 .
Key Gene Ontology (GO) terms
Molecular Function
triacylglycerol lipase activity
Biological Process
Cellular Component
Enzymatic activity
Enzyme name (EC)
triacylglycerol lipase (3.1.1.3)
Related Gene Groups
Parent group(s)
TRIGLYCERIDE LIPASES
Members (23)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
ATRLIP
ACID TRIGLYCERIDE LIPASES
Secondary FlyBase ID(s)
References (3)