FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: ROTARY ATPASE TRANSPORTERS
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General Information
Name
ROTARY ATPASE TRANSPORTERS
Species
D. melanogaster
Symbol
ROTTMT
FlyBase ID
FBgg0001894
Date last reviewed
2023-12-12
Number of members
60
Description
Description
Rotary ATPases or F-ATPase superfamily encompass the V-type, A-type and F-type ATPases. They are primary active transmembrane transporters that use the energy from the hydrolysis of the diphosphate bond of ATP to drive the transmembrane transport of an ion against a concentration or electrochemical gradient. They consist of multi-protein assemblies that assemble into distinct functional domains: a transmembrane channel, a peripheral membrane rotary ATPase and accessory subunits.
Notes on Group

Note that the F-ATPase, Mitochondrial Complex V, "runs in reverse", synthesizing ATP from ADP and inorganic phosphate using the energy provided by the proton electrochemical gradient (proton-motive force) across the inner mitochondrial membrane generated by electron transport complexes of the respiratory chain.

Source Material
The ROTARY ATPASE TRANSPORTERS Gene Group has been compiled using the following publication(s): Marygold, 2021.2.24, Sawyer et al., 2017, Bouché et al., 2016, Porcelli and Marygold, 2014.9.16, Chintapalli et al., 2013, Ilinsky, 2013, Porcelli et al., 2007, Caggese et al., 2006, Allan et al., 2005, Tripoli et al., 2005, and Dow, 1999 .
Key Gene Ontology (GO) terms
Molecular Function
primary active transmembrane transporter activity
Biological Process
transmembrane transport
Cellular Component
membrane
Enzymatic activity
Enzyme name (EC)
7.-.-.-
Related Gene Groups
Parent group(s)
P-P-BOND-HYDROLYSIS-DRIVEN TRANSPORTERS
Component group(s)
MITOCHONDRIAL COMPLEX V SUBUNITS
VACUOLAR ATPASE SUBUNITS
Members (60)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)

[Transporter Classification Database:The H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily](https://tcdb.org/search/result.php?tc=3.A.2)

Synonyms and Secondary IDs
Synonym(s)
ROTTMT
ROTARY ATPASE TRANSPORTERS
H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily
Secondary FlyBase ID(s)
References (13)