Complex: CYTOPLASMIC EXOSOME COMPLEX

General Information

Name

CYTOPLASMIC EXOSOME COMPLEX

Species

D. melanogaster

Symbol

RNA-EXOC

FlyBase ID

FBgg0001938

Date last reviewed

2026-02-03

Number of members

Description

The cytoplasmic exosome is a 3'-5' exonuclease complex involved in the processing and degradation many types of RNA which include the removal of unstable and aberrant transcripts. In yeast and humans, the exosome has a barrel structure, the core of which is formed by a ring of six RNase PH domain subunits and a cap of three S1/KH-domain subunits. (Adapted from FBrf0210381 and PMID:27345150).

Notes on Group

From studies in yeast, the cytoplasmic exosome differs from the nuclear version by the absence of the Rrp6 subunit (PMID:23352926).

The CYTOPLASMIC EXOSOME COMPLEX was sourced from Complex Portal, curated by EMBL-EBI.

Drosophila exosome complexes appear to differ from other eukaryotes as they lack an ortholog to the Rrp43 RNase PH domain subunit (FBrf0210381).

Rrp47 has not been included in the CYTOPLASMIC EXOSOME COMPLEX gene group, as it is considered to be a cofactor (FBrf0210381). CG17982 has not been included, but has been reported to co-purify with this complex under certain experimental conditions (FBrf0155992).

Source Material

The CYTOPLASMIC EXOSOME COMPLEX Gene Group has been compiled using the following publication(s): Kiss and Andrulis, 2010 .

Key Gene Ontology (GO) terms

Molecular Function

3'-5' exonuclease activity

Biological Process

RNA processing

Cellular Component

cytoplasmic exosome (RNase complex)

Related Gene Groups

Parent group(s)

RNA EXOSOME COMPLEXES