The succinate-CoA ligase (ADP/ATP) complex is a mitochondrial enzyme that catalyzes the reversible conversion of succinyl-CoA to succinate in the only step of the tricarboxylic acid cycle coupled with substrate-level phosphorylation of ADP. In eukaryotes, the functional enzyme is a heterodimeric complex composed of a single alpha subunit (that is shared with the GTP-forming complex) and a beta subunit that determines the ADP substrate specificity. (Adapted from PMID:37445899.)
Notes on Group
Note that Scsα2 is not included here - it is a testis-specific paralog of the ubiquitously expressed Scsα1 alpha subunit.
Source Material
The
SUCCINATE-COA LIGASE (ADP/ATP) COMPLEX
Gene Group has been compiled using the following publication(s):
François et al., 2023
.
