The succinate-CoA ligase (GDP/GTP) complex is a mitochondrial enzyme that catalyzes the reversible conversion of succinyl-CoA to succinate in the only step of the tricarboxylic acid cycle coupled with substrate-level phosphorylation of GDP. In eukaryotes, the functional enzyme is a heterodimeric complex composed of a single alpha subunit (that is shared with the ATP-forming complex) and a beta subunit that determines the GDP substrate specificity. (Adapted from PMID:37445899.)
Notes on Group
Note that Scsα2 is not included here - it is a testis-specific paralog of the ubiquitously expressed Scsα1 alpha subunit.
Source Material
The
SUCCINATE-COA LIGASE (GDP/GTP) COMPLEX
Gene Group has been compiled using the following publication(s):
François et al., 2023
.
