FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: GLYCOLYSIS
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General Information
Name
GLYCOLYSIS
Species
D. melanogaster
Symbol
GLYCO
FlyBase ID
FBgg0002043
Date last reviewed
2024-11-20
Number of members
12
Description
Description
Glycolysis converts glucose into ATP and pyruvate in the cytosol. The overall reaction is glucose + 2 ADP + 2Pi + 2 NAD+ -> 2 pyruvate + 2 ATP + 2 NADH 2H+ + 2 H2O and involves 10 enzymatic steps. In the presence of oxygen, pyruvate is transported into the mitochondrion where, after oxidation into acetyl-CoA, it enters the tricarboxylic acid cycle (TCA cycle). In anaerobic conditions, pyruvate is reduced to lactate in the cytosol. Although glucose, trehalose and glycogen are the main entry points for glycolysis in D. melanogaster, fructose, galactose, mannose and glycerol can also enter the glycolytic pathway to be converted into pyruvate. (Adapted from PMID:33941515 and FBrf0144936.)
Notes

Hex-T and Hexl are paralogs of Hex-A and Hex-C and are specifically expressed in testis. It is not clear if Hexl is enzymatically active as the catalytic residue is not conserved. As there is no functional information, Hex-T and Hexl are not included in the gene list. Aldol is a paralog of Aldo and is specifically expressed in testis. It is not clear if Aldol is enzymatically active as the catalytic residues are not conserved. As there is no functional information, Aldol is not included in the gene list. Gapdh3 is a paralog of Gapdh1 and Gapdh2 and is specifically expressed in testis. As there is no functional information, Gapdh3 is not included in the gene list. Pgk2 is a paralog of Pgk and is specifically expressed in testis. As there is no functional information, Pgk2 is not included in the gene list. Pgam2 and Pgaml are paralogs of Pgam1. Pgam2 is specifically expressed in testis. As there is no functional information, Pgam2 and Pgaml are not included in the gene list. Pykl1, Pykl2, Pykl3, Pykl4 and Pykl5 and are specifically expressed in testis. It is not clear if Pykl5, Pykl3, Pykl4 and Pykl5 are enzymatically active as the catalytic residues are not conserved. As there is no functional information, Pykl1, Pykl2, Pykl3, Pykl4 and Pykl5 are not included in the gene list.

Source Material
The GLYCOLYSIS Gene Group has been compiled using the following publication(s): Zappia et al., 2023, Mascolo et al., 2021, Tixier et al., 2013, and Eanes et al., 2006 .
Key Gene Ontology (GO) terms
Biological Process
canonical glycolysis
Cellular Component
cytosol
Related Gene Groups
Parent group(s)
CARBOHYDRATE METABOLISM
GO Causal Activity Model (GO-CAM)
Members (12)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[Reactome: Glycolysis](https://reactome.org/PathwayBrowser/#/R-DME-70326&SEL=R-DME-70171)

[KEGG: Glycolysis /Gluconeogenesis](https://www.kegg.jp/pathway/dme00010)

[FlyCyc: glycolysis III (from glucose)](https://biocyc.org/pathway?orgid=DMEL&id=ANAGLYCOLYSIS-PWY)

Synonyms and Secondary IDs
Synonym(s)
GLYCO
GLYCOLYSIS
Canonical glycolysis
Secondary FlyBase ID(s)
References (6)