FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: UDP-N-ACETYLGLUCOSAMINE BIOSYNTHESIS
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General Information
Name
UDP-N-ACETYLGLUCOSAMINE BIOSYNTHESIS
Species
D. melanogaster
Symbol
UDPGLAB
FlyBase ID
FBgg0002050
Date last reviewed
2024-11-20
Number of members
9
Description
Description
The synthesis of the nucleotide-sugar UDP-N-acetylglucosamine (UDP-GlcNAc) can occur via de novo or salvage pathways in the cytosol. In the de novo pathway, which is the main one, D-glucose, L-glutamine, acetyl-CoA and UTP are used to produce UDP-GlcNAc. In the salvage pathway glucosamine and N-acetylglucosamine acquired from environmental sources or from the degradation of glycoconjugates can be used to produce UDP-GlcNAc. UDP-GlcNAc is a precursor for protein glycosylation and the biosynthesis of chitin, peptidoglycans and GPI-anchors. (Adapted from PMID:37107691.)
Notes

Hex-T and Hexl are paralogs of Hex-A and Hex-C and are specifically expressed in testis. It is not clear if Hexl is enzymatically active as the catalytic residue is not conserved. As there is no functional information, Hex-T and Hexl are not included in the gene list.

Source Material
The UDP-N-ACETYLGLUCOSAMINE BIOSYNTHESIS Gene Group has been compiled using the following publication(s): Chen et al., 2020 and Mariappa et al., 2011 .
Key Gene Ontology (GO) terms
Biological Process
UDP-N-acetylglucosamine biosynthetic process
Cellular Component
cytosol
Related Gene Groups
Parent group(s)
NUCLEOTIDE-SUGAR BIOSYNTHESIS
GO Causal Activity Model (GO-CAM)
Members (9)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[Reactome: Synthesis of UDP-N-acetyl-glucosamine](https://reactome.org/PathwayBrowser/#/R-DME-446210)

[KEGG: Amino sugar and nucleotide sugar metabolism](https://www.kegg.jp/pathway/dme00520)

[FlyCyc: UDP-N-acetyl-D-glucosamine biosynthesis II](https://biocyc.org/pathway?orgid=DMEL&id=UDPNACETYLGALSYN-PWY)

Synonyms and Secondary IDs
Synonym(s)
UDPGLAB
hexosamine biosynthesis pathway
UDP-N-ACETYLGLUCOSAMINE BIOSYNTHESIS
Secondary FlyBase ID(s)
References (4)