Pathway: NUCLEOTIDE-SUGAR BIOSYNTHESIS

General Information

Name

NUCLEOTIDE-SUGAR BIOSYNTHESIS

Species

D. melanogaster

Symbol

NTSUB

FlyBase ID

FBgg0002138

Date last reviewed

2025-06-10

Number of members

Description

Nucleotide-sugars are the building blocks for the biosynthesis of polysaccharides and glycoconjugates. Most nucleotide-sugars are synthesized in the cytosol, primarily from dietary sugars, followed by their transport into the endoplasmic reticulum, the Golgi apparatus and the nucleus. In D. melanogaster, the main nucleotide-sugars are UDP-D-glucose (UDP-Glc), UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-D-galactose (UDP-Gal), UDP-N-acetylgalactosamine (UDP-GalNAc), UDP-D-glucuronate (UDP-GlcA), GDP-mannose (GDP-Man), CMP-N-acetylneuraminate (CMP-NeuNAc), GDP-L-fucose (GDP-Fuc) and UDP-D-xylose (UDP-Xyl). Together, they constitute the precursors for the synthesis of glycoproteins, glycolipids and glycosylphosphatidylinositol (GPI) anchors. In addition, UDP-Glc is used to produce glycogen and the disaccharide trehalose, while UDP-GalNAc is used for the synthesis of the polysaccharide chitin. (Adapted from PMID:34939087 and PMID:35536946.)

Notes

Source Material

The NUCLEOTIDE-SUGAR BIOSYNTHESIS Gene Group has been compiled using the following publication(s): Chen et al., 2020, Matsumoto et al., 2016, Parkinson et al., 2016, Ayukawa et al., 2012, Geisler et al., 2012, Mariappa et al., 2011, Ishikawa et al., 2010, Sanders et al., 2010, Koles et al., 2009, Rhomberg et al., 2006, Ishikawa et al., 2005, Roos et al., 2002, Goto et al., 2001, and Benevolenskaya et al., 1998 .

Key Gene Ontology (GO) terms

Biological Process

nucleotide-sugar biosynthetic process

Cellular Component

cytosol

Related Gene Groups

Parent group(s)

CARBOHYDRATE METABOLISM

Component group(s)

CMP-N-ACETYLNEURAMINATE BIOSYNTHESIS

DE NOVO GDP-FUCOSE BIOSYNTHESIS

GALACTOSE CATABOLISM