Pathway: GDP-MANNOSE BIOSYNTHESIS

General Information

Name

GDP-MANNOSE BIOSYNTHESIS

Species

D. melanogaster

Symbol

MANGPG

FlyBase ID

FBgg0002055

Date last reviewed

2024-11-20

Number of members

Description

The nucleotide-sugar GDP-D-mannose is primarily synthesized in the cytosol from D-glucose (though it can also be produced from D-mannose). GDP-D-mannose is a precursor for GDP-L-fucose biosynthesis and dolichyl β-D-mannosyl phosphate and it is directly involved in protein glycosylation. (Adapted from PMID:24931670.)

Notes

Hex-T and Hexl are paralogs of Hex-A and Hex-C and are specifically expressed in testis. It is not clear if Hexl is enzymatically active as the catalytic residue is not conserved. As there is no functional information, Hex-T and Hexl are not included in the gene list.

Source Material

The GDP-MANNOSE BIOSYNTHESIS Gene Group has been compiled using the following publication(s): Parkinson et al., 2016 .

Key Gene Ontology (GO) terms

Biological Process

GDP-mannose biosynthetic process

Cellular Component

cytosol

Related Gene Groups

Parent group(s)

NUCLEOTIDE-SUGAR BIOSYNTHESIS

GO Causal Activity Model (GO-CAM)

Members (7)