FB2026_03 , released September 17, 2026
Pathway: GALACTOSE CATABOLISM
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General Information
Name
GALACTOSE CATABOLISM
Species
D. melanogaster
Symbol
GALCA
FlyBase ID
FBgg0002056
Date last reviewed
2024-11-20
Number of members
6
Description
Description
Galactose is predominantly catabolized via the Leloir pathway into glucose 1-phosphate and UDP-α-D-galactose. Glucose 1-phosphate can be used for glycolysis after its conversion to glucose 6-phosphate by Pgm1 while UDP-α-D-galactose is a precursor for glycosaminoglycan synthesis and lipid and protein glycosylation. (Adapted from FBrf0234321.)
Notes

Galml1, Galml2 and Galml3 are paralogs of Galm1 and Galm2 and are specifically expressed in testis. It is not clear if Galml1, Galml2 and Galml3 are enzymatically active as the active site and/or the substrate binding residues are not conserved. As there is no functional information, Galml1, Galml2 and Galml3 are not included in the gene list.

Source Material
The GALACTOSE CATABOLISM Gene Group has been compiled using the following publication(s): Sanders et al., 2010 .
Key Gene Ontology (GO) terms
Biological Process
beta-D-galactose catabolic process via UDP-galactose, Leloir pathway
Cellular Component
cytosol
Related Gene Groups
Parent group(s)
NUCLEOTIDE-SUGAR BIOSYNTHESIS
GO Causal Activity Model (GO-CAM)
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Note: The Drosophila pathways shown at external resources are computed and may therefore differ from the manually curated and verified pathway shown above.
657ba49f00000239
Synonyms and Secondary IDs
Synonym(s)
GALCA
GALACTOSE CATABOLISM
Secondary FlyBase ID(s)
References (3)