The synthesis of the nucleotide-sialic acid CMP-N-acetylneuraminate (CMP-Neu5Ac) starts in the cytosol with the synthesis of Neu5Ac, which is then transported into the Golgi apparatus where it is converted into CMP-Neu5Ac. In D. melanogaster, the production of CMP-Neu5Ac occurs in glia. CMP-Neu5Ac is then exported to neurons where it is used as a precursor for the sialylation of glycoconjugates. (Adapted from FBrf0207553.)
CMP-N-ACETYLNEURAMINATE BIOSYNTHESIS
Notes
In D. melanogaster, the enzyme(s) involved in the production of aldehydo-N-acetyl-D-mannosamine 6-phosphate is/are not known.
Source Material
The
CMP-N-ACETYLNEURAMINATE BIOSYNTHESIS
Gene Group has been compiled using the following publication(s):
Koles et al., 2009
.
Unable to display GO ribbon stack for gene groups with more than 100 members.
External Data
Note: The Drosophila pathways shown at external resources are computed
and may therefore differ from the manually curated and verified pathway shown above.
