FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: GDP-MANNOSE BIOSYNTHESIS FROM GLUCOSE
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General Information
Name
GDP-MANNOSE BIOSYNTHESIS FROM GLUCOSE
Species
D. melanogaster
Symbol
MANGPG
FlyBase ID
FBgg0002055
Date last reviewed
2024-11-20
Number of members
7
Description
Description
The nucleotide-sugar GDP-D-mannose is primarily synthesized in the cytosol from D-glucose (though it can also be produced from D-mannose). GDP-D-mannose is a precursor for GDP-L-fucose biosynthesis and dolichyl β-D-mannosyl phosphate and it is directly involved in protein glycosylation. (Adapted from PMID:24931670.)
Notes

Hex-T and Hexl are paralogs of Hex-A and Hex-C and are specifically expressed in testis. It is not clear if Hexl is enzymatically active as the catalytic residue is not conserved. As there is no functional information, Hex-T and Hexl are not included in the gene list.

Source Material
The GDP-MANNOSE BIOSYNTHESIS FROM GLUCOSE Gene Group has been compiled using the following publication(s): Parkinson et al., 2016 .
Key Gene Ontology (GO) terms
Biological Process
GDP-D-mannose biosynthetic process from fructose-6-phosphate
Cellular Component
cytosol
Related Gene Groups
Parent group(s)
NUCLEOTIDE-SUGAR BIOSYNTHESIS
GO Causal Activity Model (GO-CAM)
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[Reactome: Synthesis of GDP-mannose](https://reactome.org/PathwayBrowser/#/R-DME-446205)

[KEGG: Fructose and mannose metabolism](https://www.kegg.jp/pathway/dme00051)

[FlyCyc: GDP-mannose biosynthesis](https://biocyc.org/pathway?orgid=DMEL&id=PWY-5659)

Synonyms and Secondary IDs
Synonym(s)
MANGPG
GDP-MANNOSE BIOSYNTHESIS FROM GLUCOSE
Secondary FlyBase ID(s)
References (3)