Pathway: GALACTOSE CATABOLISM

General Information

Name

GALACTOSE CATABOLISM

Species

D. melanogaster

Symbol

GALCA

FlyBase ID

FBgg0002056

Date last reviewed

2024-11-20

Number of members

Description

Galactose is predominantly catabolized via the Leloir pathway into glucose 1-phosphate and UDP-α-D-galactose. Glucose 1-phosphate can be used for glycolysis after its conversion to glucose 6-phosphate by Pgm1 while UDP-α-D-galactose is a precursor for glycosaminoglycan synthesis and lipid and protein glycosylation. (Adapted from FBrf0234321.)

Notes

Galml1, Galml2 and Galml3 are paralogs of Galm1 and Galm2 and are specifically expressed in testis. It is not clear if Galml1, Galml2 and Galml3 are enzymatically active as the active site and/or the substrate binding residues are not conserved. As there is no functional information, Galml1, Galml2 and Galml3 are not included in the gene list.

Source Material

The GALACTOSE CATABOLISM Gene Group has been compiled using the following publication(s): Sanders et al., 2010 .

Key Gene Ontology (GO) terms

Biological Process

galactose catabolic process via UDP-galactose, Leloir pathway

Cellular Component

cytosol

Related Gene Groups

Parent group(s)

NUCLEOTIDE-SUGAR BIOSYNTHESIS

GO Causal Activity Model (GO-CAM)

Members (6)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

External Data

Other resource(s)

Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[Reactome: Galactose catabolism](https://reactome.org/PathwayBrowser/#/R-DME-70370)

[KEGG: Galactose degradation, Leloir pathway](https://www.kegg.jp/pathway/dme00052)

[FlyCyc: D-galactose degradation I (Leloir pathway)](https://biocyc.org/pathway?orgid=DMEL&id=PWY-6317)

Synonyms and Secondary IDs

Synonym(s)

GALCA

GALACTOSE CATABOLISM

Secondary FlyBase ID(s)

References (3)

Report Sections

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