The malate-aspartate shuttle is composed of two cytosolic enzymes, two mitochondrial enzymes and two transporters. It is used to transport reducing equivalents from the cytosol to the mitochondrion, since cytosolic NADH cannot cross the inner mitochondrial membrane directly. The shuttle regenerates cytosolic NAD(+) to sustain cytosolic oxidative pathways such as glycolysis and provides reducing equivalents in the form of NADH for mitochondrial oxidative phosphorylation. (Adapted from PMID:38945121.)
MALATE-ASPARTATE SHUTTLE
Notes
CG10748 and CG10749 are paralogs of Mdh2 and are specifically expressed in testis. As there is no functional information, CG10748 and CG10749 are not included in the gene list.
Source Material
The
MALATE-ASPARTATE SHUTTLE
Gene Group has been compiled using the following publication(s):
Lunetti et al., 2021
.
Unable to display GO ribbon stack for gene groups with more than 100 members.
External Data
Note: The Drosophila pathways shown at external resources are computed
and may therefore differ from the manually curated and verified pathway shown above.
