Gene Group: PYRROLINE-5-CARBOXYLATE DEHYDROGENASES

General Information

Name

PYRROLINE-5-CARBOXYLATE DEHYDROGENASES

Species

D. melanogaster

Symbol

P5CDH

FlyBase ID

FBgg0002083

Date last reviewed

2025-09-04

Number of members

Description

Pyrroline-5-carboxylate dehydrogenases catalyze the irreversible oxidation of glutamate-gamma-semialdehyde to glutamate in the mitochondrial matrix. This is the second step of the proline degradation pathway. These enzymes can also oxidize other 1-pyrrolines. (Adapted from FBrf0257593.)

Notes on Group

CG6661 is a testis-enriched P5CDh paralog, but the encoded protein lacks conserved residues in the active site and NAD+ binding site. It is therefore classed as a pseudoenzyme and excluded from this group.

Source Material

The PYRROLINE-5-CARBOXYLATE DEHYDROGENASES Gene Group has been compiled using the following publication(s): Holmes, 2023 and He and DiMario, 2011 .

Key Gene Ontology (GO) terms

Molecular Function

L-glutamate gamma-semialdehyde dehydrogenase (NAD+) activity

Biological Process

Cellular Component

mitochondrial matrix

Enzymatic activity

Enzyme name (EC)

L-glutamate gamma-semialdehyde dehydrogenase (1.2.1.88)

Related Gene Groups

Parent group(s)

ALDEHYDE OR OXO OXIDOREDUCTASES, NAD OR NADP AS ACCEPTOR