Complex: TIM23 MITOCHONDRIAL IMPORT INNER MEMBRANE SORT COMPLEX

General Information

Name

TIM23 MITOCHONDRIAL IMPORT INNER MEMBRANE SORT COMPLEX

Species

D. melanogaster

Symbol

TIM23-SORT

FlyBase ID

FBgg0002163

Date last reviewed

2026-03-26

Number of members

Description

The TIM23 SORT complex mediates the import and lateral insertion of mitochondrial presequence-containing proteins into the inner mitochondrial membrane. Following translocation of proteins across the outer mitochondrial membrane by the TOM complex, presequence-containing proteins are passed to the TIM23 complex. In the TIM23 SORT variant, TIMM21 replaces the presequence translocase-associated motor (of the TIM23 MOTOR complex, that mediates import into the matrix) and facilitates lateral insertion of proteins into the inner membrane. Lateral insertion is independent of ATP-hydrolysis and dependent on membrane potential. (Adapted from PMID:32074073,PMID:38828998 and PMID:19884344.)

Notes on Group

The TIM23 MITOCHONDRIAL IMPORT INNER MEMBRANE SORT COMPLEX represents a ubiquitously expressed complex subunits compiled using high-throughput expression data. Subunit paralogs with a strong testis expression bias CG1724, Tim17a1, Tim17a2, Tim17b1, Tim17b2, ttm3, ttm2 have been excluded but can be found in the gene group TIM23 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE COMPLEX SUBUNITS.

Source Material

The TIM23 MITOCHONDRIAL IMPORT INNER MEMBRANE SORT COMPLEX Gene Group has been compiled using the following publication(s): Žarsky and Doležal, 2016, Lotz et al., 2014, and Sugiyama et al., 2007 .

Key Gene Ontology (GO) terms

Molecular Function

protein transporter activity

membrane insertase activity

Biological Process

protein insertion into mitochondrial inner membrane

Cellular Component

mitochondrial inner membrane

Related Gene Groups

Parent group(s)

MITOCHONDRIAL PROTEIN IMPORT COMPLEXES

Other related group(s)