FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: L-ASPARTATE AND L-ASPARAGINE METABOLISM
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General Information
Name
L-ASPARTATE AND L-ASPARAGINE METABOLISM
Species
D. melanogaster
Symbol
ASPASNM
FlyBase ID
FBgg0002185
Date last reviewed
2025-01-27
Number of members
3
Description
Description
L-aspartate and L-asparagine are non-essential amino-acids. L-aspartate can be produced from L-glutamate as part of the malate-aspartate shuttle. Besides its role in protein synthesis, L-aspartate is a precursor for beta-alanine and is involved in purine biosynthesis and L-arginine metabolism. L-asparagine can be synthesized from L-aspartate in the cytosol by AsnS and is used for protein synthesis. (Adapted from FBrf0262112.)
Notes

CG7860, CG6428 and CG8526 are predicted to have asparaginase activity. However, it is not known if this is their physiological activity in D. melanogaster. ASRGL1, the human homolog of CG7860 is an isoaspartyl peptidase and ASPG, the homolog of CG6428 and CG8526 is a lysophospholipase. As there is no functional information, CG7860, CG6428 and CG8526 are not included in the gene list.

Source Material
The L-ASPARTATE AND L-ASPARAGINE METABOLISM Gene Group has been compiled using the following publication(s): Luo et al., 2025 and Chase and Kankel, 1987 .
Key Gene Ontology (GO) terms
Biological Process
L-asparagine biosynthetic process
L-aspartate biosynthetic process
Cellular Component
cytosol
mitochondrion
Related Gene Groups
Parent group(s)
AMINO ACID METABOLISM
Other related group(s)
MALATE-ASPARTATE SHUTTLE
GO Causal Activity Model (GO-CAM)
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[FlyCyc: L-aspartate biosynthesis](https://biocyc.org/pathway?orgid=DMEL&id=ASPARTATESYN-PWY)

[FlyCyc: L-asparagine biosynthesis I](https://biocyc.org/pathway?orgid=DMEL&id=ASPARAGINE-BIOSYNTHESIS)

[Reactome: Aspartate and asparagine metabolism](https://reactome.org/PathwayBrowser/#/R-DME-8963693)

[KEGG: Alanine, aspartate and glutamate metabolism](https://www.kegg.jp/kegg-bin/show_pathway?dme00250)

Synonyms and Secondary IDs
Synonym(s)
ASPASNM
L-ASPARTATE AND L-ASPARAGINE METABOLISM
L-asparagine biosynthesis
L-aspartate biosynthesis
Secondary FlyBase ID(s)
References (3)