FB2026_03 , released September 17, 2026
Gene Group: HOLDASES
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General Information
Name
HOLDASES
Species
D. melanogaster
Symbol
HOLD
FlyBase ID
FBgg0002250
Date last reviewed
2026-07-30
Number of members
25
Description
Description
Holdases bind to a protein in an unfolded or nascent state to prevent aggregation or misfolding before handing it on to another gene product or complex for transport or folding, for example. Holdases are ATP-independent. (Adapted from PMID:39488384 and PMID:33315891.)
Notes on Group
Source Material
The HOLDASES Gene Group has been compiled using the following publication(s): Attrill, 2024.1.5, Attrill, 2024.9.5, Jagla et al., 2018, Vos et al., 2016, Zhang et al., 2016, Zhang et al., 2011, Takahashi et al., 2010, Li et al., 2009, Morrow et al., 2006, and Michaud et al., 2002 .
Key Gene Ontology (GO) terms
Molecular Function
unfolded protein holdase activity
Biological Process
Cellular Component
Related Gene Groups
Component group(s)
PREFOLDIN HOLDASES
SMALL HEAT SHOCK PROTEINS
SMALL TIMS
Members (25)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
HOLD
HOLDASES
Holdase chaperones
Secondary FlyBase ID(s)
References (11)