Prefoldins are holdases that bind unfolded polypeptides and maintain them in a folding-competent state. The canonical eukaryotic prefoldins form a heterohexameric complex that binds actin and tubulin co-translationally and delivers them to the chaperonin containing TCP-1 (CCT) complex. (Adapted from FBrf0231608 and PMID:29427249.)