Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\DNase2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\DNase2 in JBrowse3-45.9
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
There is evidence for two other alkaline deoxyribonuclease genes. One produces a band on denatured substrate at pH 8.5 and is localized to 3L on the basis of different mobilities in D.melanogaster and D.simulans (FBrf0028810). The other is located in 97F-100F based on increased alkaline DNase activity in hyperploids for that region (FBrf0063659); segmental aneuploidy failed to identify the other two regions as affecting DNase levels (FBrf0063659).
The structural gene for a deoxyribonuclease that is active on heat-denatured DNA at pH 8.5. Causes the appearance of two bands on polyacrylamide gels. Null allele without detectable phenotypic effect.
