Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Is using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Is in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Increased dosage of the Is locus suppresses the triplolethal, but not the haplolethal phenotype of Tpl. Altered dosage of Is in the presence of two copies of Tpl has no obvious effects. Is probably does not directly repress Tpl expression, but rather acts downstream of the Tpl triplo-lethal phenotype.
Lethality of three doses of Tpl can be rescued by dosage of the Is locus.
The lethality of triploids for the Tpl locus is rescued by dosage changes at Is.
Named after the Egyptian goddess Isis, who resurrected her brother Osiris after he was killed.