Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sesD using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\sesD in JBrowse1-23.8
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutations of sesD cause abnormalities in the electroretinogram (ERG) and/or prolonged depolarization after potential (PDA): slow recovery from the PDA. Mutations affect retinula cell physiology.
mosaic analysis suggests stress-induced paralysis of legs associated with sesD maps to separate foci, since the individual appendages can be paralyzed independently in such gynandromorphs (Homyk, unpublished); sesD1's developmental temperature-sensitive lethality originally said (Homyk et al., 1980) to be caused by separate mutation on the X chromosome, but turned out not to be the case (Homyk, unpublished).
Paralyzed by mechanical shock; one allele (sesD2) causes constitutive inactivity, poor jumping and flying ability, abnormal landing responses and feeble male courtship (Homyk et al., 1980); this allele also leads to longer stress-induced paralysis than does sesD1; the latter is a temperature-sensitive developmental lethal. In addition, sesD1 is reversibly temperature sensitive for the following visual phenotype, shown by electroretinogram recordings (Homyk and Pye, 1989): at temperatures <30oC, orange-light-elicited recovery from blue-induced prolonged depolarizing afterpotential (PDA) is slow and orange responses induced after recovery are aberrantly low-amplitude; at higher temperatures, orange-induced recovery from PDA involves incomplete repolarization, so that potential levels off below baseline extant before exposure to blue light; this persists even after continued orange stimulation or in the dark; under these conditions, orange light also leads to light-on and light-off ERG transient spikes with anomalously low amplitudes; these heat-induced effects are quickly reversible (to normal ERG/PDA-associated potentials) when temperature lowered to 25oC.
Complements adult-lethal-1, which maps nearby; rex does, too, but it maps to 7C1-3 (Homyk and Pye, 1989).
