FB2026_02 , released June 18, 2026
Gene: Drer\shha
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General Information
Symbol
Drer\shha
Species
D. rerio
Name
sonic hedgehog a
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0019631
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
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All Summaries
Also Known As

sonic hedgehog, shh

Key Links
Foreign Gene Data

Foreign sequence; species == Danio rerio; gene == shha; ZFIN:ZDB-GENE-980526-166.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
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Other relevant insertions
Transgenic Constructs ( 2 )
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Transgenic constructs containing/affecting coding region of Drer\shha
Transgenic constructs containing regulatory region of Drer\shha
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (0)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Stocks (0)
    Other Comments

    Ectopic expression of Brer\shh has a similar effect as ectopic expression of hh though Brer\shh has an attenuated effect on imaginal disc patterning. Reorganisation of the anterior wing is presaged by ectopic expression of dpp and ptc.

    (Ingham and Fietz, 1995)

    Brer\shh can act in the same pathway as the endogenous hh, overexpression in Drosophila embryos activates hh-dependent pathway.

    (Krauss et al., 1993)
    Relationship to Other Genes
    Source for database merge of
    Additional comments
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (7)
    Reported As
    Symbol Synonym
    Brer\shh
    Drer\shh
    Drer\shha
    shh
    (Niki, 2006, Niki et al., 2006)
    shha
    Name Synonyms
    sonic hedgehog
    (Ingham and Fietz, 1995, Krauss et al., 1993)
    sonic hedgehog a
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 1 )
      Other crossreferences
      ZFIN - Zebrafish Model Organism Database
      References (8)