FB2026_02 , released June 18, 2026
Gene: Hsap\SMAD4
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General Information
Symbol
Hsap\SMAD4
Species
H. sapiens
Name
SMAD family member 4
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0024343
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Smad4

Key Links
Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == SMAD4; HGNC:6770.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsap\SMAD4
Transgenic constructs containing regulatory region of Hsap\SMAD4
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal - majority live, with Scer\GAL4Dll-md23
Other Phenotypes
Allele
visible, with Scer\GAL4A9
visible, with Scer\GAL4ptc-559.1
Phenotype manifest in
Allele
campaniform sensillum, with Scer\GAL4Bx-MS1096
campaniform sensillum, with Scer\GAL4C-765
campaniform sensillum, with Scer\GAL4T80
denticle row 1, with Scer\GAL4en-e16E
leg, with Scer\GAL4ptc-559.1
leg | ectopic, with Scer\GAL4ptc-559.1
mechanosensory ventral triple row bristle, with Scer\GAL4Bx-MS1096
medial row of triple row of wing sensilla | ectopic, with Scer\GAL4Bx-MS1096
medial row of triple row of wing sensilla | ectopic, with Scer\GAL4C-765
medial row of triple row of wing sensilla | ectopic, with Scer\GAL4T80
wing, with Scer\GAL4A9
wing, with Scer\GAL4ptc-559.1
wing margin, with Scer\GAL4A9
wing vein | ectopic, with Scer\GAL4A9
wing vein | ectopic, with Scer\GAL4ptc-559.1
wing vein L2, with Scer\GAL4A9
wing vein L3, with Scer\GAL4Bx-MS1096
wing vein L4, with Scer\GAL4A9
wing vein L5, with Scer\GAL4A9
wing vein L5, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (6)
Med
12 of 14
Yes
Yes
0  
Dad
3 of 14
No
No
0  
Mad
2 of 14
No
No
0  
Smox
2 of 14
No
No
0  
exp
1 of 14
No
Yes
0  
reb
1 of 14
No
Yes
0  
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
Summary of Genetic Interactions
Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
Class of Gene
Stocks and Reagents
Stocks (0)
Other Comments

Hsap\MADH1 or Hsap\MADH4, as well as Mad or Med, can stimulate dpp signalling in limb development. Hsap\MADH2, Hsap\MADH4 and Med stimulate activin-β- rather than dpp-mediated cell proliferation.

(Marquez et al., 2001)

Overexpression of Med or Hsap\MADH4 in the wing and leg causes a similar phenotype. The leg phenotype caused by overexpression of Med or Hsap\MADH4 is similar to that caused by overexpression of Hsap\MADH6 or Hsap\MADH7.

(Marquez et al., 2001)
Relationship to Other Genes
Source for database merge of
Additional comments

FlyBase curator comment: Symbol and name changed to reflect current HGNC symbol and name (19th Nov. 2012).

(FlyBase Curators, 1992-)
Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs (12)
Reported As
Symbol Synonym
DPC4
(HGNC Curators and FlyBase Curators, 2013-)
Hsap\MADH4
Hsap\SMAD4
Hsap\Smad4
(Newfeld et al., 2005)
MADH4
(HGNC Curators and FlyBase Curators, 2013-)
SMAD4
(HGNC Curators and FlyBase Curators, 2013-, Takaesu et al., 2005, Hudson et al., 1998)
Smad4
(Stinchfield et al., 2012, Johnson et al., 1999, Hudson et al., 1998)
hSmad4
(Marquez et al., 2001)
Name Synonyms
MAD, mothers against decapentaplegic homolog 4 (Drosophila)
(HGNC Curators and FlyBase Curators, 2013-)
Mothers against decapentaplegic homolog 4
SMAD family member 4
(HGNC Curators and FlyBase Curators, 2013-)
SMAD, mothers against DPP homolog 4 (Drosophila)
(HGNC Curators and FlyBase Curators, 2013-)
Secondary FlyBase IDs
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    External Crossreferences and Linkouts ( 9 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    Other crossreferences
    Ensembl_Homo_sapiens -
    HUGO Gene Nomenclature Committee -
    MARRVEL - MARRVEL (human gene)
    OMIM_GENE - Online Mendelian Inheritance in Man (Genes)
    OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)
    References (11)