FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Hsap\SMAD3
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General Information
Symbol
Hsap\SMAD3
Species
H. sapiens
Name
SMAD family member 3
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0027385
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == SMAD3; HGNC:6769.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsap\SMAD3
Transgenic constructs containing regulatory region of Hsap\SMAD3
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4unspecified
Other Phenotypes
Allele
increased cell death, with Scer\GAL4en-e16E
increased cell death, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4A9
Phenotype manifest in
Allele
wing, with Scer\GAL4A9
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (6)
Smox
11 of 14
Yes
Yes
0  
Mad
5 of 14
No
No
0  
Dad
2 of 14
No
No
0  
Med
2 of 14
No
No
0  
exp
1 of 14
No
Yes
0  
reb
1 of 14
No
Yes
0  
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Stocks (0)
    Other Comments

    Overexpression of Hsap\MADH3 can inhibit cell proliferation or stimulate apoptosis during wing development.

    (Marquez et al., 2001)
    Relationship to Other Genes
    Source for database merge of
    Additional comments

    FlyBase curator comment: Symbol and name changed to reflect current HGNC symbol and name (19th Nov. 2012).

    (FlyBase Curators, 1992-)
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (12)
    Reported As
    Symbol Synonym
    HsT17436
    (HGNC Curators and FlyBase Curators, 2013-)
    Hsap\MADH3
    Hsap\SMAD3
    JV15-2
    (HGNC Curators and FlyBase Curators, 2013-)
    MADH3
    (HGNC Curators and FlyBase Curators, 2013-)
    SMAD3
    (HGNC Curators and FlyBase Curators, 2013-)
    Smad3
    (Johnson et al., 1999)
    hSmad3
    (Marquez et al., 2001)
    Name Synonyms
    MAD, mothers against decapentaplegic homolog 3 (Drosophila)
    (HGNC Curators and FlyBase Curators, 2013-)
    Mothers against decapentaplegic homolog 3
    SMAD family member 3
    (HGNC Curators and FlyBase Curators, 2013-)
    SMAD, mothers against DPP homolog 3 (Drosophila)
    (HGNC Curators and FlyBase Curators, 2013-)
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 6 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      Other crossreferences
      Ensembl_Homo_sapiens -
      HUGO Gene Nomenclature Committee -
      MARRVEL - MARRVEL (human gene)
      OMIM_GENE - Online Mendelian Inheritance in Man (Genes)
      OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)
      References (5)