FlyBase Gene Report: Hsap\SMAD2

General Information

Symbol

Hsap\SMAD2

Species

H. sapiens

Name

SMAD family member 2

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0044437

Gene Model Status

Not Applicable

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

hSmad2

Key Links

Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == SMAD2; HGNC:6768.

(FlyBase Curators, 1992-)

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hsap\SMAD2

Transgenic constructs containing regulatory region of Hsap\SMAD2

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

wing, with Scer\GAL4^A9

Hsap\SMAD2^UAS.cMa

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (6)

Smox

10 of 14

Yes

Mad

5 of 14

Dad

2 of 14

Med

2 of 14

exp

1 of 14

Yes

reb

1 of 14

Yes

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Hsap\SMAD2^UAS.cMa

ameliorates generalized dystonia

modeled by Hsap\TOR1A^ΔE.UAS

(Koh et al., 2004)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

Stocks and Reagents

Stocks (0)

Other Comments

Hsap\MADH2, Hsap\MADH4 and Med stimulate activin-β- rather than dpp-mediated cell proliferation.

(Marquez et al., 2001)

Overexpression of Med, Smox, Hsap\MADH2 or Hsap\MADH4 causes a similar phenotype in the wing.

(Marquez et al., 2001)

Relationship to Other Genes

Source for database merge of

Additional comments

FlyBase curator comment: Symbol and name changed to reflect current HGNC symbol and name (19th Nov. 2012).

(FlyBase Curators, 1992-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

Hsap\MADH2

Hsap\SMAD2

Hsap\Smad2

(Newfeld et al., 2005)

JV18-1