FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Xlae\nog.L
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General Information
Symbol
Xlae\nog.L
Species
X. laevis
Name
noggin
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0290476
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Foreign Gene Data

Foreign sequence; species == Xenopus laevis; gene == nog.L; Xenbase:XB-GENE-864891.

(FlyBase Curators, 1992-)

Foreign sequence; species == Xenopus laevis; gene == 'noggin'; UniProt:P49011.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Xlae\nog.L
Transgenic constructs containing regulatory region of Xlae\nog.L
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (0)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Stocks (0)
    Other Comments

    Expression of Xlae\noggin has ventralizing activity on expression in embryos.

    (Holley et al., 1996)

    Xlae\noggin ventralizes Drosophila embryos by preventing dpp from activating its receptor. Xlae\noggin blocks dpp signalling upstream of dpp receptor activation.

    (Holley et al., 1996)
    Relationship to Other Genes
    Source for database merge of
    Additional comments
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    Noggin
    (Jones, 1999)
    Xlae\nog.L
    Xlae\noggin
    nog.L
    noggin
    Name Synonyms
    noggin
    Secondary FlyBase IDs
    • FBgn0288869
    • FBgn0016115
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    External Crossreferences and Linkouts ( 1 )
    Other crossreferences
    Xenbase - Xenbase Database
    References (9)