FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: multiple endocrine neoplasia
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General Information
Name
multiple endocrine neoplasia
FlyBase ID
FBhh0000005
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes general characteristics of the group of diseases classified as multiple endocrine neoplasias (MEN). MEN is a genetically heterogeneous disorder, with several causative genes and mapped loci. A listing of MEN subtypes, as defined by OMIM, may be found in the table below, with links to more detailed reports for subtypes that have been investigated using fly models.

[updated Feb. 2015 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: multiple endocrine neoplasia
OMIM report
Symptoms and phenotype

For additional information on classification and genetics see http://www.thyroidcancer.com/thyroid-cancer/medullary/genetics.

(FlyBase Curators, 2013-)

Multiple endocrine neoplasias are characterized by varying combinations of tumors derived from endocrine glands, including parathyroid, thyroid, pituitary, and adrenal glands. Frequently the tumors are nonmetastasizing, but can cause serious clinical effects due to the inappropriate secretion of endocrine substances. [from MIM:131100, MIM:171400, MIM:162300; 2014.07.03]

(OMIM, 2013-)
Genetics
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
MEN
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (4)