FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: prostate cancer
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General Information
Name
prostate cancer
FlyBase ID
FBhh0000461
Disease Ontology Term
Parent Disease
OMIM
PROSTATE CANCER
Overview

This report contains general information about prostate cancer and links to review(s) describing disease models in flies. Multiple loci have been implicated in hereditary prostate cancer; many additional loci appear to confer susceptibility to the disease. Specific models developed in Drosophila are listed in the 'Related Diseases' section below.

[updated Dec. 2020 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: prostate cancer
OMIM report

[PROSTATE CANCER](https://omim.org/entry/176807)

Human gene(s) implicated

[MITOTIC ARREST DEFICIENT 1 LIKE 1; MAD1L1](https://omim.org/entry/602686)

[KLF TRANSCRIPTION FACTOR 6; KLF6](https://omim.org/entry/602053)

[PHOSPHATASE AND TENSIN HOMOLOG; PTEN](https://omim.org/entry/601728)

[MAX-INTERACTING PROTEIN 1; MXI1](https://omim.org/entry/600020)

[BRCA2 DNA REPAIR-ASSOCIATED PROTEIN; BRCA2](https://omim.org/entry/600185)

[ZINC FINGER HOMEOBOX 3; ZFHX3](https://omim.org/entry/104155)

[CHECKPOINT KINASE 2; CHEK2](https://omim.org/entry/604373)

Symptoms and phenotype

Prostate cancer is the most common cancer in American men and is usually very slowly progressive; it is diagnosed in an estimated 80% of men who reach age 80 (http://www.webmd.com/prostate-cancer; 2016.12.20).

(FlyBase Curators, 2013-)
Genetics
Cellular phenotype and pathology

Prostatic adenocarcinoma is the most frequent form of prostate cancer and accounts for 90 to 95% of prostate cancer. Prostatic adenocarcinoma occurs in the cells lining the glandular organ of the prostate, the area responsible for the secretion of the chemicals that make up a large portion of seminal fluid. Typically, prostatic adenocarcinoma is a slow growing form of cancer. (American Cancer Society; http://www.crs-src.ca/page.aspx?pid=1801; 2016.12.20)

(FlyBase Curators, 2013-)
Molecular information
External links
Disease synonyms
prostate cancer, familial
prostate cancer, hereditary
prostate cancer, susceptibility to
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (3)