FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: schizophrenia, susceptibility to
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General Information
Name
schizophrenia, susceptibility to
FlyBase ID
FBhh0000526
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes general characteristics of schizophrenia (SCZD), specifically subtypes that confer susceptibility to schizophrenia. Schizophrenia is highly heritable but the genetics are complex; multiple loci that appear to confer susceptibility to the disease have been identified. A phenotypic series for subtypes of schizophrenia has not been defined by OMIM as of this update; see MIM:181500.

[updated Apr. 2017 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: schizophrenia, susceptibility to
OMIM report
Symptoms and phenotype

See also 'Schizophrenia: Symptoms, causes, and treatments' (http://www.medicalnewstoday.com/articles/36942.php).

(FlyBase Curators, 2013-)

Schizophrenia is a psychosis, a disorder of thought and sense of self. Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Schizophrenia often develops in young adults who were previously normal, and is characterized by a constellation of symptoms including hallucinations and delusions (psychotic symptoms) and symptoms such as severely inappropriate emotional responses, disordered thinking and concentration, erratic behavior, as well as social and occupational deterioration (Andreasen, 1995; pubmed:7637483). [from MIM:181500; 2017.04.18]

(OMIM, 2013-)
Genetics

Schizophrenia is a common disorder with a lifetime prevalence of approximately 1%. It is highly heritable, but the genetics are complex. [from MIM:181500; 2017.04.18]

(OMIM, 2013-)
Cellular phenotype and pathology

There is no characteristic pathology associated with schizophrenia (such as neurofibrillary tangles in Alzheimer disease). [from MIM:181500; 2017.04.18]

(OMIM, 2013-)
Molecular information
External links
Disease synonyms
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (11)