Autism and schizophrenia co-occur significantly more often than would be expected by chance. A meta-analysis collating data from 11 studies found that schizophrenia is approximately 3.6 times as common in individuals with autism as in controls. Reciprocally, autism was found more often in people with schizophrenia than in the general population, although the data, taken from 6 studies, were too variable to establish an approximate frequency. [Zheng et al. 2018; pubmed:30284394; https://www.spectrumnews.org/news/schizophrenia-prevalence-may-threefold-higher-people-autism/]
A number of genes in human have been implicated in both autism spectrum disorder and schizophrenia. Cases that have been studied in flies include NRXN1 (FBhh0000516), MAPK3 (FBhh0000842), ABCA13 (FBhh0001047), TAOK2 (FBhh0001219), DISC1 (FBhh0000529) and RIMS1 (FBhh0001277, FBhh0001359).
[updated Jun. 2021 by FlyBase; FBrf0222196]
