- Tools
- Downloads
- Links
- Community
- About
- Help
FB2026_03
,
released September 17, 2026
The human BOD1 gene has been identified as a candidate locus for development of intellectual disability (FBrf0232363). The BOD1 protein is required for proper chromosome bi-orientation on mitotic spindles, the process during which each sister kinetochore forms microtubule attachments to only one spindle pole. There is a single orthologous Drosophila gene, Dmel\BOD1, for which RNAi-targeting constructs have been generated. Dmel\BOD1 is orthologous to two additional human genes, BOD1L2 and BOD1L1.
A UAS construct of a tagged wild-type human Hsap\BOD1 gene has been introduced into flies and has been made available; it has not been characterized.
Neuron-specific RNAi-effected knockdown of Dmel\BOD1 causes learning deficits in adults and abnormalities in synapse morphology in third instar larvae.
[updated Apr. 2018 by FlyBase; FBrf0222196]
BOD1 protein is required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. [Gene Cards, BOD1; 2017.09.08]
Many to one: 3 human to 1 Drosophila; the human genes are BOD1, BOD1L2, BOD1L1.
Many to one: 3 human to 1 Drosophila; the human genes are BOD1, BOD1L2, BOD1L1.
Many to one: 3 human to 1 Drosophila; the human genes are BOD1, BOD1L2, BOD1L1.
Moderate to low-scoring ortholog of human genes BOD1, BOD1L2, BOD1L1 (1 Drosophila to 3 human). The 3 human proteins vary significantly in length; the amino terminus of the fly gene shares 42-46% identity and 63-68% similarity with the shorter human genes, BOD1 and BOD1L2. The fly gene aligns along its entire length to the amino half of BOD1L1, with 21% identity and 34% similarity.