FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: Parkinson-like disease, MPP/MPTP-induced
Open Close
General Information
Name
Parkinson-like disease, MPP/MPTP-induced
FlyBase ID
FBhh0000736
Disease Ontology Term
Parent Disease
OMIM
Overview

Parkinson disease has been studied using Drosophila models in which neurodegenerative symptoms are produced by administration of MPP (N-methyl-4-phenylpyridinium) or MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). MPP is the major metabolite of MPTP; MPTP was the causative agent of a cluster of acute Parkinson-like cases in 1982 that were traced to contaminated synthetic heroin. See FlyBase chemical reports for MPP (FBch0000982) and MPTP (FBch0000994, FBch0002718).

[updated Dec. 2024 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: Parkinson-like disease, MPP/MPTP-induced
OMIM report
Human gene(s) implicated
Symptoms and phenotype

MPTP is the causative agent of a cluster of acute Parkinson-like cases reported in and around 1982; MPTP was found to be a contaminant of synthetic heroin. Patients exhibited virtually all of the motor features of typical Parkinsons disease and some of the non-motor aspects; symptoms were responsive to L-dopa. MPTP has been used extensively in mammalian models of Parkinson disease. (Langston, 2017; pubmed:28282815)

(FlyBase Curators, 2013-)
Genetics
Cellular phenotype and pathology
Molecular information

In mammals, MPTP (1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine) is metabolized in the liver; its main metabolite is MPP+ (1-methyl-4-phenylpyridinium ion) (Algeri, et al., 1987; pubmed:3500067).

(FlyBase Curators, 2013-)

MPTP, as a lipophilic compound, can pass into the brain; there it is converted into the toxic metabolite MPP+. (Langston, 2017; pubmed:28282815)

(FlyBase Curators, 2013-)
External links
    Disease synonyms
    Parkinson disease, MPP-induced
    Parkinson-like disease, chemically-induced
    Parkinson-like disease, MPP-induced
    Parkinson-like disease, MPTP-induced
    Parkinson-like disease, MPTP model
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (28)