FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: Parkinson-like disease, toxin-induced
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General Information
Name
Parkinson-like disease, toxin-induced
FlyBase ID
FBhh0000187
Disease Ontology Term
Parent Disease
OMIM
Overview

Parkinson-like disease phenotypes have been studied using Drosophila models in which locomotor defects and other neurodegenerative symptoms are produced by exposure to various toxins. Most frequently used are the pesticide rotenone and the herbicide paraquat. These models have been used extensively to characterize possible therapeutic regimens.

See FlyBase chemical reports for rotenone (FBch0000521) and paraquat (FBch0000495).

[updated Jan. 2024 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: Parkinson-like disease, toxin-induced
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    paraquat intoxication
    Parkinson disease, chemically-induced
    Parkinson disease, toxin-induced
    Parkinson-like disease, chemically-induced
    PQ-induced PD
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (177)