The offspring of bisphenol A (BPA)-exposed adults were assessed for the behavioral alterations analogous to those associated with autism, including patterns of locomotion, repetitive behaviors, and social interaction behaviors. Changes is exploratory behavior, an increase in grooming behavior, and uncharacteristic social interactions were observed. This effect has since been observed consequent to exposure to other bisphenol compounds, including bisphenol F (BPF) and 4,4'-sulfonyldiphenol (bisphenol S, BPS).
See the FlyBase chemical reports for bisphenol A (FBch0000077), bisphenol F (FBch0001575), and 4,4'-sulfonyldiphenol (FBch0001576).
[updated Feb. 2026 by FlyBase; FBrf0222196]
Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypic, and ritualized patterns of interests and behavior (Bailey et al., 1996, pubmed:8655659; Risch et al., 1999, pubmed:10417292). 'Autism spectrum disorder,' sometimes referred to as ASD, is a broader phenotype encompassing the less severe disorders Asperger syndrome (MIM:608638) and pervasive developmental disorder, not otherwise specified (PDD-NOS). 'Broad autism phenotype' includes individuals with some symptoms of autism, but who do not meet the full criteria for autism or other disorders. Mental retardation coexists in approximately two-thirds of individuals with ASD, except for Asperger syndrome, in which mental retardation is conspicuously absent (Jones et al., 2008; pubmed:18698615). [from MIM:209850; 2021.02.28]
