FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: high-protein diet, insulin pathway effects
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General Information
Name
high-protein diet, insulin pathway effects
FlyBase ID
FBhh0000895
Disease Ontology Term
Parent Disease
OMIM
Overview

The impact of a high-protein diet upon insulin signaling has been investigated in Drosophila. It has been shown that regulation of insulin secretion via insulin-like peptides differs for high-protein and high-sugar diets: amino acids promote the secretion of insulin-like peptide 2 (Ilp2) by the insulin-producing cells (IPCs); circulating sugars promote the selective release of Ilp3 from the IPCs.

[updated Sep. 2018 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: high-protein diet, insulin pathway effects
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
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          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
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          Publicly Available Stocks
          Selected Drosophila transgenes
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          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
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          Publicly Available Stocks
          References (4)