FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: cancer, epithelial, STX7,12-related
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General Information
Name
cancer, epithelial, STX7,12-related
FlyBase ID
FBhh0000969
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes a model of epithelial cancer using the Drosophila syntaxin gene Syx7; there are two human genes orthologous to Dmel\Syx7 : STX7 and STX12. The syntaxin gene family encodes membrane receptors involved in vesicle transport as components of SNARE (SNAP receptor) complexes. Neither human gene has been implicated in cancer. Classical loss-of-functions mutations, RNAi-targeting constructs, and alleles caused by insertional mutagenesis have been generated for Dmel\Syx7.

Neither human gene, STX7 or STX12, has been introduced into flies.

Animals homozygous for an amorphic allele of Dmel\Syx7 die during the larval stage. Assayed in imaginal discs, somatic clones homozygous for an amorphic allele of Dmel\Syx7 are slow-growing and usually eliminated from the disc. Very large clones produced using the Minute system exhibit epithelial disorganization and undergo massive overproliferation during an extended larval stage.

[updated Feb. 2019 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: cancer, epithelial, STX7,12-related
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information

The syntaxin gene family encodes membrane receptors involved in vesicle transport as components of SNARE (SNAP receptor) complexes. The STX7 protein mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. STX12 is a component of a SNARE complex that acts to regulate protein transport between late endosomes and the trans-Golgi network. [Gene Cards, STX7, STX12; 2019.02.12]

(FlyBase Curators, 2013-)

Note that STX13 has been determined to be the same gene as STX12.

(FlyBase Curators, 2013-)

Collins et al. (2002, pubmed:12218144) showed that STX7 and STX12 are involved in the ordered fusion of endosomes and lysosomes with the phagosome, where phagocytic cells kill and degrade internalized foreign particles. STX12 is localized to the recycling endosome compartment, while STX7 is found in late endosomes and lysosomes and both are recruited to the phagosome. However, STX12 is acquired earlier before rapidly recycling off the phagosome, while STX7 is recruited later and continues to accumulate throughout the phagosome maturation process. [from MIM:606892; 2019.02.13]

(OMIM, 2013-)
External links
Disease synonyms
Search term: endolysosomal trafficking
Search term: endosomal trafficking
Search term: hyperplastic phenotypes
Search term: SNARE protein
Ortholog Information
Human gene(s) in FlyBase
    Human gene (HGNC)
    Symbol / Name
    STX12; syntaxin 12
    D. melanogaster ortholog (based on DIOPT)
    Dmel\Syx7
    (DIOPT, 2013-)
    Comments on ortholog(s)

    Many to one (2 human to 1 Drosophila); additional related genes in both species.

    Human gene (HGNC)
    Symbol / Name
    STX7; syntaxin 7
    D. melanogaster ortholog (based on DIOPT)
    Dmel\Syx7
    (DIOPT, 2013-)
    Comments on ortholog(s)

    Many to one (2 human to 1 Drosophila); additional related genes in both species.

    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (1)
      Dmel\Syx7
      Gene Snapshot
      Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome. [Date last reviewed: 2019-03-14]
      Molecular function (GO)
      Cellular component (GO)
      Gene Groups / Pathways
      Comments on ortholog(s)

      High-scoring ortholog of human STX7 and STX12 (1 Drosophila to 2 human); additional related genes in both species. Dmel\Syx7 shares 33-41% identity and 58-59% similarity with human STX7 and STX12.

      Orthologs and Alignments from DRSC
      DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
      H. sapiens (Human)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (37 groups)
        Syx7
        protein-protein
        Interacting group
        Assay
        References
        Syx7 - αSnap
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - AttD
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Bet1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - CG3164
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - CG7668
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - CG14767
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - CG15098
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - fax
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Frl
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - γSnap1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - γSnap2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Gos28
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Hsap\APOL1
        anti tag coimmunoprecipitation, anti tag western blot
        (Lee et al., 2023)
        Syx7 - koko
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Membrin
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Past1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Pvr
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Sec20
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Sec22
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Slh
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Snap24
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Snap25
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Snap29
        experimental knowledge based, anti bait coimmunoprecipitation, peptide massfingerprinting
        (Morelli et al., 2014, Guruharsha et al., 2011)
        Syx7 - Syb
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Syx1A
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Syx4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Syx5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Syx8
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Syx13
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Syx16
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Syx18
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Use1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Vamp7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Syx7 - Vha100-1
        anti bait coimmunoprecipitation, western blot, pull down
        (Williamson et al., 2010)
        Syx7 - Vps33B
        anti bait coimmunoprecipitation, anti tag western blot
        (Akbar et al., 2009)
        Syx7 - Vps45
        pull down, anti tag western blot
        (Morrison et al., 2008)
        Syx7 - Ykt6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Alleles Reported to Model Human Disease (Disease Ontology) (6 alleles)
        Syx7
        Models Based on Experimental Evidence ( 3 )
        Allele
        Disease
        Evidence
        References
        Syx71
        model of  carcinoma
        CEA
        (Lu and Bilder, 2005)
        Syx7GD2767
        model of  cancer
        CEA
        (Santabárbara-Ruiz and Léopold, 2021)
        Syx73119
        model of  cancer
        CEA with Ras85DV12.cUa.UAS
        (Liu et al., 2022)
        Modifiers Based on Experimental Evidence ( 5 )
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Syx7hs.PL
        P{hs-Syx7.L}
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Syx7RNAi.UAS.cUa
        P{UAS-Syx7.RNAi.U}
        Syx7RNAi.UAS.cLa
        P{UAS-Syx7.RNAi.L}
        Syx7GD2767
        P{GD2767}
        w1118; P{GD2767}v5413
        Syx7KK101990
        P{KK101990}
        P{KK101990}VIE-260B
        Syx7JF02436
        P{TRiP.JF02436}
        y1 v1; P{TRiP.JF02436}attP2
        Syx7NIG.5081R
        P{NIG.5081R}
        P{NIG.5081R}4
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        Syx73119
        ethyl methanesulfonate
        Syx71
        loss of function allele
        w*; P{neoFRT}80B Syx71/TM6B, Tb1
        Syx7G6457
        P-element activity
        y1 w*; P{EP}Syx7G6457/TM3, Sb1 Ser1
        References (11)