FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Syx71
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General Information
Symbol
Dmel\Syx71
Species
D. melanogaster
Name
FlyBase ID
FBal0195590
Feature type
allele
Associated gene
Dmel\Syx7
Associated Insertion(s)
Carried in Construct
Also Known As
avl1
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Lu and Bilder, 2005)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: E181term.

    (Lu and Bilder, 2005)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:21,447,285..21,447,285 [+]
    Nucleotide change:

    G21447285T

    Amino acid change:

    E181term | Syx7-PA; E181term | Syx7-PB

    Reported amino acid change:

    E181term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Lu and Bilder, 2005)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  carcinoma
        CEA
        (Lu and Bilder, 2005)
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        model of  carcinoma
        is ameliorated by Syx7hs.PL
        (Lu and Bilder, 2005)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Cells mutant for Syx71 in mosaic eye discs are eliminated by cell competition. The resulting adult eyes are grossly morphologically normal and contain wild-type ommatidia.

        (Vaccari et al., 2009)

        Oocytes derived from homozygous germline clones lack yolk granules.

        (Morrison et al., 2008)

        Syx71 mosaic eyes are morphologically normal.

        (Vaccari et al., 2008)

        Mutant eye discs (generated using the eyFLP-cell lethal system) show disorganised cellular architecture and reduced differentiation compared to wild type.

        Larvae containing mutant eye discs generated using the eyFLP-cell lethal system are increased in size compared to control larvae when examined as pupariation commences. The animals do not develop into adults.

        (Menut et al., 2007)

        In contrast to the cuboidal monolayer of follicle cells seen in wild type, follicle cells homozygous for Syx71 are rounded and form multilayers at the ovary poles.

        Syx71 germ-line clones do not produce fertilized eggs.

        Syx71 clones produced in imaginal discs are slow-growing and usually eliminated.

        Eye imaginal discs that consist predominantly of Syx71 mutant clones (produced using the "eyFLP/Minute" system) show marked epithelial disruption: the apical-basal polarity of mutant cells is disrupted, ectopic adherens junctions form, and the mutant discs undergo massive overproliferation during an extended larval period, resulting in the development of tumour-like growths. Syx71 mutant discs isolated immediately before pupariation contain approximately 2.5 times as many cells as wild type controls.

        Both homozygous and hemizygous Syx71 animals die as first instar larvae.

        (Lu and Bilder, 2005)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Other
        Statement
        Reference

        Scer\GAL4en-e16E, Syx71/Syx7[+], Vps45RNAi.UAS.WIZ has visible phenotype

        (Morrison et al., 2008)
        Phenotype Manifest In
        Other
        Statement
        Reference

        Scer\GAL4en-e16E, Syx71/Syx7[+], Vps45RNAi.UAS.WIZ has wing phenotype

        (Morrison et al., 2008)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of Vps45dsRNA.Scer\UAS.WIZ under the control of Scer\GAL4en-e16E in a Syx71/+ background results in defects in the wing.

        (Morrison et al., 2008)

        Adult eyes developing from Syx71 TSG1012 mosaic discs display mild bulging, which is consistent with intermediate levels of N signaling hyper-activation.

        (Vaccari et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Syx71 is rescued by Syx7hs.PL

        (Lu and Bilder, 2005)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        References (9)