FB2026_03 , released September 17, 2026
Human Disease Model Report: prostate cancer, accessory gland models
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General Information
Name
prostate cancer, accessory gland models
FlyBase ID
FBhh0001600
Disease Ontology Term
Parent Disease
OMIM
Overview

The human prostate is a gland of the male reproductive tract which, together with the seminal vesicles, is responsible for most seminal fluid production. In Drosophila, the male accessory glands make many major seminal fluid components and are in many aspects the functional equivalent of the human prostate. Mechanisms driving prostate epithelial tumorigenesis, such as basal epithelial cell extrusion, are being studied in flies using the male accessory gland. In some cases, the model involves expression in the accessory glands of established drivers of tumorigenesis in flies (for example, Ras85DV12; see FBhh0000474).

For reviews promoting this type of prostate cancer model, including detailed descriptions of the functional analogies of the human prostate and Drosophila male accessory glands, see Wilson et al., 2017 (FBrf0234322) and Rambur et al., 2021 (FBrf0251378).

[updated Aug. 2024 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: prostate cancer, accessory gland models
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
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    Disease synonyms
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
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          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
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          Publicly Available Stocks
          Selected Drosophila transgenes
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          RNAi constructs available
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          Selected Drosophila classical alleles
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          References (8)