FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Prosα6, Prosβ5
FlyBase ID
FBig0000009584
Interaction Network
Interactions Browser links
Prosα6 network
Prosβ5 network
Reported Interactions
FBrf0218395-10476.DPiM
Reference
Guruharsha et al., 2011
Description
physical association
Assay
Collection
DPiM-2
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Prosβ5 
unspecified role
Prosβ5 
unspecified role
Prosβ5 
unspecified role
Prosα6 
unspecified role
Prosα6 
unspecified role
Prosα6 
unspecified role
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

HGScore = 708.39642

FBrf0221748-13.coIP.WB
Reference
Tsakiri et al., 2013
Description
physical association
Assay
Collection
Source/Stage
ovary / femaleadult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Prosα6 

20S-α

bait
Prosβ5 

β5

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was ovaries of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Tsakiri et al., 2013)

Level of assembled 20S proteasome did not decrease in ovaries of aged flies. Level of assembled 20S proteasome is greater in gonads than in somatic tissue.

(Tsakiri et al., 2013)
FBrf0221748-20.coIP.WB
Reference
Tsakiri et al., 2013
Description
physical association
Assay
Collection
Source/Stage
spermatheca / maleadult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Prosα6 

20S-α

bait
Prosβ5 

β5

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was spermathecae of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Tsakiri et al., 2013)

Level of assembled 20S proteasome is greater in gonads than in somatic tissue.

(Tsakiri et al., 2013)
FBrf0221748-6.coIP.WB
Reference
Tsakiri et al., 2013
Description
physical association
Assay
Collection
Source/Stage
somatic cell / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Prosα6 

20S-α

bait
Prosβ5 

β5

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult somatic tissues of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Tsakiri et al., 2013)

Level of assembled 20S proteasome decreased in somatic tissues of aged flies.

(Tsakiri et al., 2013)
FBrf0222671-6.coIP.WB
Reference
Tsakiri et al., 2013
Description
physical association
Assay
Collection
Source/Stage
somatic cell / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Prosα6 

20S-α

bait
Prosβ5 

β5

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult somatic tissues of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Tsakiri et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)