FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
veli, CASK
FlyBase ID
FBig0000061743
Interaction Network
Interactions Browser links
veli network
CASK network
Reported Interactions
FBrf0174808-3.Y2H
Reference
Bachmann et al., 2004
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
veli 

DLin-7

bait

fused to GAL4 DNA-binding domain

CASK 

Dlin-2/CAKI

prey

fused to GAL4 activation domain

CASK 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
CASK 
L27 domainS
sufficient binding region
aa 312-495

897 residue isoform tested

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Two-hybrid system: yeast GAL4-BD/GAL4-AD

(Bachmann et al., 2004)

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Bachmann et al., 2004)

veli binds sdt and CASK more strongly than dlg1 in this assay.

(Bachmann et al., 2004)
FBrf0218395-6029.DPiM
Reference
Guruharsha et al., 2011
Description
physical association
Assay
Collection
DPiM-2
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
CASK 
unspecified role
CASK 
unspecified role
CASK 
unspecified role
veli 
unspecified role
veli 
unspecified role
veli 
unspecified role
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

HGScore = 101.36447

External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)