FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Hipk, gro
FlyBase ID
FBig0000095410
Interaction Network
Interactions Browser links
Hipk network
gro network
Reported Interactions
FBrf0187785-1.ENZ.A
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hipk 

DHIPK2

enzyme

GST tag

Hipk 

DHIPK2

enzyme

GST tag

gro 

GRO

enzyme target

GST tag, P[32] label

gro 

GRO

enzyme target

GST tag, P[32] label

gro 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0206915-1.ENZ
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hipk 

Hipk

enzyme

GST tag

Hipk 

Hipk

enzyme

GST tag

gro 

Gro

enzyme target

[32]P label

gro 

Gro

enzyme target

[32]P label

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0206915-2.ENZ
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hipk 

Hipk

enzyme

GST tag

Hipk 

Hipk

enzyme

GST tag

gro 

Gro

enzyme target

[32]P label

gro 

Gro

enzyme target

[32]P label

gro 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0206915-3.ENZ
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hipk 

Hipk

enzyme

GST tag

Hipk 

Hipk

enzyme

GST tag

gro 

Gro

enzyme target

[32]P label

gro 

Gro

enzyme target

[32]P label

gro 
gro 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0226612-1.ENZ.A
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hipk 

Hipk

enzyme

GST tag

Hipk 

Hipk

enzyme

GST tag

gro 

Gro

enzyme target

GST tag, P[32] label

gro 

Gro

enzyme target

GST tag, P[32] label

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0226612-4.BiFC.FM
Reference
Dewald et al., 2014
Description
physical association
Assay
Collection
Source/Stage
wing disc / third instar larval stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hipk 

Hipk

neutral component

YFP tag, N-terminal fragment

Hipk 

Hipk

neutral component

YFP tag, N-terminal fragment

Hipk 

Hipk

neutral component

YFP tag, N-terminal fragment

gro 

Gro

neutral component

YFP tag, C-terminal fragment

gro 

Gro

neutral component

YFP tag, C-terminal fragment

gro 

Gro

neutral component

YFP tag, C-terminal fragment

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was larval wing discs; proteins produced from transfected constructs.

(Dewald et al., 2014)
FBrf0238258-3.ENZ.A
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hipk 

Hipk

enzyme

GST tag

Hipk 

Hipk

enzyme

GST tag

gro 

Gro

enzyme target

GST tag, P[32] label

gro 

Gro

enzyme target

GST tag, P[32] label

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0238258-6.BiFC.FM
Reference
Steinmetz et al., 2018
Description
physical association
Assay
Collection
Source/Stage
wing disc / larval stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hipk 

Hipk

bait

YFP tag, N-terminal fragment

gro 

Gro

prey

YFP tag, C-terminal fragment

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was larval wing discs of transgenic fly line; proteins produced from transgenic constructs.

(Steinmetz et al., 2018)

Positive control.

(Steinmetz et al., 2018)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (4)