FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
lin-52, E2f2
FlyBase ID
FBig0000095662
Interaction Network
Interactions Browser links
lin-52 network
E2f2 network
Reported Interactions
FBrf0219063-13.CH.WB
Reference
Lewis et al., 2012
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage 1embryonic stage 15blastoderm stagegastrula stageembryonic stage 8embryonic stage 9embryonic stage 6early extended germ band stageembryonic cycle 3extended germ band stageembryonic stage 4embryonic stage 2embryonic cycle 9late extended germ band stageembryonic stage 5embryonic stage 12embryonic stage 11embryonic stage 3embryonic cycle 6embryonic cycle 8embryonic cycle 5embryonic cycle 7embryonic stage 13embryonic cycle 4embryonic stage 14embryonic stage 10embryonic stage 7
Cell line used
Participants
Corresponds to
Reported as
Role
Note
lin-52 

Lin-52

bait

FLAG tag

E2f2 

E2F2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Bait derived from a transgenic line carrying a FLAG-tagged lin-52 construct in a lin-52[93] homozygous mutant background.

(Lewis et al., 2012)

Prey endogenous to embryonic nuclear extract and coimmunoprecipitated with FLAG-tagged lin-52.

(Lewis et al., 2012)

E2f2 associates with lin-52 as part of the MMB/dREAM complex.

(Lewis et al., 2012)

lin-52 fractionates exclusively with components of the MMB/dREAM complex.

(Lewis et al., 2012)

Proteins associated with affinity purified FLAG-tagged lin-52 were subjected to gel filtration.

(Lewis et al., 2012)
FBrf0219063-7.coIP.WB
Reference
Lewis et al., 2012
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage 1embryonic stage 15blastoderm stagegastrula stageembryonic stage 8embryonic stage 9embryonic stage 6early extended germ band stageembryonic cycle 3extended germ band stageembryonic stage 4embryonic stage 2embryonic cycle 9late extended germ band stageembryonic stage 5embryonic stage 12embryonic stage 11embryonic stage 3embryonic cycle 6embryonic cycle 8embryonic cycle 5embryonic cycle 7embryonic stage 13embryonic cycle 4embryonic stage 14embryonic stage 10embryonic stage 7
Cell line used
Participants
Corresponds to
Reported as
Role
Note
lin-52 

Lin-52

bait

FLAG tag

E2f2 

E2F2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Bait derived from a transgenic line carrying a FLAG-tagged lin-52 construct in a lin-52[93] homozygous mutant background.

(Lewis et al., 2012)

Prey endogenous to embryonic nuclear extract.

(Lewis et al., 2012)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)