FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
sicily, Hsp83
FlyBase ID
FBig0000096860
Interaction Network
Interactions Browser links
sicily network
Hsp83 network
Reported Interactions
FBrf0221023-5.coIP.MS
Reference
Zhang et al., 2013
Description
physical association
Assay
Collection
Source/Stage
organism / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
sicily 

sicily

bait

mCherry tag

Hsp83 

Hsp90

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adults of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Zhang et al., 2013)

Tagged sicily immunoprecipitated using RFP nanobodies.

(Zhang et al., 2013)
FBrf0221023-6.coIP.WB
Reference
Zhang et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
sicily 

sicily

bait

V5 tag

Hsp83 

Hsp90

prey

GFP tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Zhang et al., 2013)

Reductions in Hsp83 activity (by RNAi or the inhibitor geldanamycin) reduce the level of sicily protein.

(Zhang et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)